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 姓名:杨志荣 性别:男
职称:教授 学院:生命科学学院
研究方向:资源微生物学、生态环境保护
联系方式:13981833388 85460487(办公室)85415232(住宅)
Email:bioyang@163.com
 
四川大学生物工程研究所所长
四川省学术与技术带头人
国务院政府特殊津贴获得者
中国微生物学会理事
四川省微生物学会副理事长
四川省植物保护学会理事四川省生物技术协会理事
成都市特聘反恐工作专家。
 
教育经历
1973.09-1977.01,四川大学生物系,学士学位
 
工作经历
1977.02-1986.06 四川大学生命科学系,助教
1986.07- 1992.06,四川大学生命科学系,讲师
1992.07-1996.10,四川大学生命科学学院,副教授
1996.11- 1998.07,四川大学生命科学学院,教授,博士生导师
1998.07-2005.08,四川大学生命科学学院,教授、博士生导师、副院长
2004.12 人选四川省学术与技术带头人
 
项目主持情况:
先后主持国家级科研项目10余项、国家自然科学基金4项、省部级科研项目20多项。现主持国家支撑计划项目1项(生物源毒鼠药剂的研发与应用,经费:175万元),四川省科技支撑计划项目2项(若尔盖湿地保护的关键技术研究与示范,经费:50万元;甘孜、阿坝种植中药材生态治沙关键技术与示范,经费:300万元),横向合作项目1项。作为主研人员参加的国家的国际合作项目1项, 省部级项目3项。
 
个人介绍:
在国内外首次分离发现了草原毛虫核型多角体病毒、栗黄枯叶蛾核型多角体病毒、盗毒蛾核型多角体病毒等三种昆虫病毒;一种新的昆虫病原微生物――类产碱假单胞菌;从该昆虫病原微生物中发现了一种新的杀虫蛋白;并成功地克隆到该杀虫蛋白基因,该基因已获得国家发明专利;并将该杀虫基因成功地构建了具有杀虫效果的抗虫转基因牧草新材料,抗虫转基因牧草新材料已经获得了国家发明专利。
在人类肿瘤的发生机制与肿瘤治疗研究方面,探明了大肠癌的一种发生机制,该研究结果于2010年发表在美国科学院院报(PNAS),该研究结果在国内外都引起了巨大反应;在真菌研究方面,应用真菌多糖治疗肿瘤的研究,取得了很好的结果,研制出三种真菌多糖保健品。
在国内外首次研制出草原毛虫核型多角体病毒杀虫剂和细菌灭蝗剂,现已获得国家新农药登记,并在青藏高原草地大面积应用于草原毛虫和蝗虫防治;应用肉毒梭状芽孢杆菌产生的A型肉毒毒素研制成生物灭鼠剂防治草原鼠害,长期在青藏高原草地大面积应用。
从2000年以来,从事生态环境保护的研究与应用,成功地研究出青藏高原退化草地和沙化草地的治理模式与治理技术体系;高寒退化湿地生态系统恢复模式与恢复技术体系。
 
科研成果
2006年以来发表的部分重要学术论文(仅列SCI收录论文)
(1) Qiang Luo, Qun Sun, Lisa Wu, Zhirong Yang. Structural characterization of an immunoregulatory polysaccharide from the fruiting bodies of Lepista sordida. Carbohydrate Polymers. doi:10.1016/j.carbpol.2011.12.0433. (通讯作者) (2) Fan Luo, Su Feng, Qun Sun, Wenliang Xiang, Jian Zhao, Jie Zhang, Zhirong Yang, Screening for bacteriocin-producing lactic acid bacteria from kurut, a traditional naturally-fermented yak milk from QinghaieTibet plateau. Food Control, 2011, 22:50-53. (通讯作者)
(3) Qiang Luo, Jie Zhang, Liang Yan, Yuanlin Tang, Xiang Ding, Zhirong Yang, and Qun Sun. Composition and Antioxidant Activity of Water-Soluble Polysaccharides from Tuber indicum. Journal of Medicinal Food. 14 (0) 2011, 1–8.
(4) Xiang Ding, Su Feng, Mei Cao, Maotao Li, Jie Tang, Chun-xiao Guo, Jie Zhang,Qun Sun, Zhirong Yang, Jian Zhao. Structure characterization of polysaccharide isolated from the fruiting bodies of Tricholoma matsutake. Carbohydrate Polymers, 2010, 81:942-947.
(5) Yiqing Zhao, Xiaodong Zhang, Kishore Guda, Earl Lawrence, Qun Sun, Toshio Watanabe, Yoichiro Iwakura, Masahide Asano, LanlanWei, Zhirong Yang,Weiping Zheng, Dawn Dawson, JosephWillis, Sanford D. Markowitz, Masanobu Sataked, and Zhenghe Wang. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proceedings of the National Academy of Sciences (PNAS), 2010, 107: 2592-2597.
(6) Wei Wei, Linyong Zheng, Mengyao Yu, Nan Jiang, Zhirong Yang, Xia Luo. Anti-fatigue activity of extract form the submerged fermentation of Ganoderma Lucidum using Radix astragali as substrate. Journal of Animal & Plant Sciences, 2010, 6: 677- 684.
(7) Linyong Zheng, Dinghong Jia, Xiaofan Fei, Xia Luo, Zhirong Yang, An assessment of the genetic diversity within Ganoderma strains with AFLP and ITS PCR-RFLP. Microbiological Research, 2009, 164: 312-321. (通讯作者)
(8) Mengyao Yu, Xiaoyan Xu, Yuan Qing Xia Luo, Zhirong Yang, Linyong Zheng. Isolation of an anti-tumor polysaccharide from Auricularia polytricha (jew’s ear) and its effects on macrophage activation. Eur Food Res Technol, 2009, 228: 477–485.
(9)Mei Zeng Yilu Lu1, Xiaolin Liao1, Dan Li Huaqin Sun1, Suhua Liang Sizhong Zhang1, Yongxin Ma and Zhirong Yang ,DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression MOLECULAR BIOLOGY REPORTS 卷: 36 期: 8 页: 2009 2399-2403
(10)Hao Chen Chaorong Peng , Yongyi Yao Jingxia Wang Zhuping Chen Zhirong Yang Lijun Xia Siyang Liu ,Preparation and Characterization of poly(L-lactide) Membranes Prepared by gamma-Radiation-Induced Grafting of N-Vinyl Pyrrolidone JOURNAL OF APPLIED POLYMER SCIENCE 5 2009 3152-3157
(11)Jiang LH, Shi Y, Wang LS, Yang ZR ,The influence of orally administered docosahexaenoic acid on cognitive ability in aged mice JOURNAL OF NUTRITIONAL BIOCHEMISTRY 2009 735-741
(12)Chen Q, Cao M, Xiang WL, Sun Q, Zhang J, Hou RT, Yan ZY, Yang ZR, Liu J, Zhao J.,STUDY ON GENES WITH ALTERED EXPRESSION IN alpha-AMANITIN POISONED MICE AND EVALUATION ON ANTAGONISTIC EFFECTS OF TRADITIONAL CHINESE MEDICINES AGAINST TOXICITY OF alpha-AMANITIN ACTA BIOLOGICA HUNGARICA 2009 281-291
(13)Jie Zhang Jian Zhao Daxu Li Sujun Liu1, Li Li Qun Sun1, Ming Huang and Zhirong Yang, Cloning of the gene encoding an insecticidal protein in Pseudomanas pseudoalcaligenes ANNALS OF MICROBIOLOGY 2009 45-50
(14)Huang Min Da-Xu Li Wen-Liang Xiang Chen Hao Jian-Hua Guo Zhao Jian Zhang Jie Zhi-Rong Yang Sun Qun ,
Effect of the untranslated region and signal peptide sequence of the insecticidal gene from Pseudomonas pseudoalcaligenes on the activity of its expression products in tobacco WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2009 619-625
(15)Wenliang Xiang Jianhua Guo Wei Feng Min Huang Hao Chen Jian Zhao Jie Zhang Zhirong Yang1 and Qun Sun,Community of extremely halophilic bacteria in historic Dagong Brine Well in southwestern China WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2008 2297-2305
(16)GUO Jian-Hua ; XIANG Wen-Liang ; ZHAO Qing-Rong ; TAO LUO ; MIN HUANG ; JIE ZHANG ; JIAN ZHAO ; YANG Zhi-Rong ; QUN SUN Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Sichuan Province in China JAPANESE JOURNAL OF INFECTIOUS DISEASES 2008 264-268
(17)Luo X (Luo, Xia) Xu XY Yu MY) Yang ZR Zheng LY ,Characterisation and immunostimulatory activity of an alpha-(1 -> 6)-D-glucan from the cultured Armillariella tabescens mycelia FOOD CHEMISTRY 15 2008 357-363
(18)Zou LK , Wang HN Pan X Tian GB Xie ZW Wu Q Chen H Xie T Yang ZR Expression, purification and characterization of a phyA(m)-phyCs fusion phytase JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE 2008 536-545
(19)Zeng M Sun HQ Chen S Wang XY Yang Y Liu YQ Tao DC Yang ZR Zhang SZMa YX ,Identification of target messenger RNA substrates for mouse RBMY OLECULAR HUMAN REPRODUCTION 2008 331-336
(20)Zhe R Zhang MY Kitazato K Kobayash N Zhu QC Zhang PZ Yang ZR Wang YF , Effect of siRNA on HSV-1 plaque formation and relative expression levels of UL39 mRNA ARCHIVES OF VIROLOGY 2008 1401-1406
Effect of siRNA on HSV-1 plaque formation and relative expression levels of UL39 mRNA
(21)Chen S, Xin Y, Zhan Y, Yang ZR. Synthesis and antimicrobial activities of brominated dihydroxy nitro diphenyl ethers CHINESE JOURNAL OF ORGANIC CHEMISTRY 2008 498-502
(22) Mengyao Yu Bo Ma1, Xia Luo Linyong Zheng Xiaoyan Xu and Zhirong Yang ,Molecular diversity of Auricularia polytricha revealed by inter-simple sequence repeat and sequence-related amplified polymorphism markers CURRENT MICROBIOLOGY
2008 240-245
(23)Hai-Long Sun, Shao-Cai Li Wen-Lan Xiong Zhi-Rong Yang, Bao-Shan Cui and Tao-Yang ,Influence of slope on root system anchorage of Pinus yunnanensis ECOLOGICAL ENGINEERING 3 2008 60-67
(24)邹燕 吴洁,侯若彤,吴凯群, 王玉良,陈淑华,杨志荣,王玉忠,Study on the synthesis and bactericidal activities of new brominated hydroxy diphenyl ether CHINESE JOURNAL OF ORGANIC CHEMISTRY 2008 111-114
(25)Shu-Lin Zhang, Jian-Guo Shen, Gwan-Han Shen, Zhan-Qiang Sun, Ping-Hui Xu, Yi-Li Peng, Zhi-Rong Yang and Qun Sun ,Use of a novel multiplex probe array for rapid identification of Mycobacterium species from clinical isolates WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2007 1779-1788 出版年:
(26)Zhang SL , Shen JG, Xu PH, Li DX, Sun ZQ, Li L, Yang ZR, Sun Q A novel genotypic test for rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates by a multiplex probe array JOURNAL OF APPLIED MICROBIOLOGY 2007 1262-1271
(27)Jin D, Lu W, Ping SZ, Zhang W, Chen J, Dun BQ, Ma RQ, Zhao ZL, Sha JY, Li L, Yang ZR, Chen M , Lin M ,Identification of a new gene encoding EPSPS with high glyphosate resistance from the metagenomic library CURRENT MICROBIOLOGY 2007350-355
(28)Li SC , Sun HL, Yang ZR, Xiong WL, Cui BS Root anchorage of Vitex negundo L. on rocky slopes under different weathering degrees ECOLOGICAL ENGINEERING 1 2007 27-33
(29)Zhang SL, Qi H (, Qiu DL, Li DX, Zhang J, Du CM, Wang GB, Yang ZR, Sun Q ,Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from Central China BIOCHEMICAL GENETICS 2007 281-290
(30)Zhao J, Cao M, Zhang J Yang ZR ,Pathological effects of the mushroom toxin alpha-amanitin on BALB/c mice PEPTIDES 2006 3047-3052
(31)Zhao J , Cao M, Zhang J, Sun Q, Chen Q, Yang ZR ,Cloning and expression of a 5-enolpyruvylshikimate-3-phosphate synthase gene from Halomonas variabilis DNA SEQUENCE 208-214 2006
(32)Jin H, Chen S, Hou RT, Wang YL, Chen SH, Yang ZR Study on the synthesis and antimicrobial activities of brominated dihydroxy diphenyl ethers CHINESE JOURNAL OF ORGANIC CHEMISTRY 2006 1424-1428
(33)Liu SJ, Luo X, Li DX, Zhang J, Qiu DL, Liu W, She LA, Yang ZR, Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC INTERNATIONAL IMMUNOPHARMACOLOGY : 2006 1387-1393
(34)Liu Z, Lu W, Chen M, Yang ZR, Lin M ,Genetic analysis of glyphosate tolerance in Halomonas variabilis strain HTG(7) WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2006 681-686
(35)Li L, Zhang J, Zhu JQ, Gu S, Sun Q, Zhou GM, Fu CX, Li Q, Yang ZR, Genetic diversity of nine populations of the black goat (Capra hircus) in Sichuan, PR china ZOOLOGICAL SCIENCE 2006 229-234 出版年:
(36)Li DX, Zhang J, Zhao J, Zhang Y, Chen F, Zhu JQ, Liu SJ, Yang ZR, Plant regeneration via somatic embryogenesis of Elymus sibiricus cv. 'chuancao No. 2' PLANT CELL TISSUE AND ORGAN CULTURE 2006 285-292
(37) Yi Y, Cao Y, Li Q, Liu M, Cheng L, Bai LH, Yang ZR, Qiao DR, Cloning and sequence analysis of the gene encoding (6-4)photolyase from Dunaliella salina BIOTECHNOLOGY LETTERS 2006 309-314
(38)Ke YP, Sun Q, Yang ZR, Xin JJ, Chen L, Hou XD, Determination of trace cadmium and zinc in corn kernels and related soil samples by atomic absorption and chemical vapor generation atomic fluorescence after microwave-assisted digestion SPECTROSCOPY 2006 29-43
 
获得的科技成果
(1)草原毛虫病毒杀虫剂研制及大面积推广应用 国家科技进步三等奖 1998
(2)草原毛虫核型多角体病毒的基础与应用研究 四川省科技进步一等奖 1985
(3)草原毛虫病毒杀虫剂研制及在草原大规模应用 教育部科技进步一等奖 1990
(4)细菌防治蝗虫的基础与应用研究 四川省科技进步一等奖 1998
(5)优质多抗超高产玉米川单15号的选育及应用 四川省科技进步一等奖 2004
(6)茶毛虫核型多角体病毒的应用研究 四川省科技进步二等奖 1982
(7)茶毛虫病毒杀虫剂研制与应用 教育部科技进步二等奖 1986
(8)生化灭鼠剂的研制及在草原鼠害防治中的应用 教育部科技进步二等奖 1991
(9)稻粒黑粉病的病理组织切片与防治技术研究 四川省科技进步二等奖 2000
(10)四川各地黑山羊生产性能与遗传特征研究 四川省科技进步二等奖 2006
还获得过省部级科技成果三等奖六项
 
获得的优秀教学成果奖
(1)生物科学本科创新实验体系的建立与实践 国家高优秀教学成果二等奖 2006
(2)生物科学本科创新实验体系的建立与实践 四川省优秀教学成果一等奖 2006
(3)非生物类本科生物学教学的研究与实践 湖北省高优秀教学成果一等奖 2006
 
获得的国家发明专利
(1)类产检假单胞菌杀虫蛋白基因 发明型专利 专利号ZL 2003101109082.X, 2007
(2)川草二号老芒麦转抗虫基因技术,发明型专利 专利号ZL 200510021175.1, 2009;
(3)短芒披碱草转杀虫蛋白基因的技术方法 发明型专利 专利号ZL 200510022401.8,2009;
(4)一种预防与治疗慢性肝纤维化和肝硬化的中药制剂,发明型专利 专利号
(5)ZL 200610022478.X,2008;
.一种快速高效的玉米穿梭系谱育种法,发明型专利 专利号ZL031358705,2005。
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